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2’,3’-Didehydro-3’-deoxythymidine-5’-triphosphate (d4T-TP, Stavudine triphosphate)

Features: Chain terminator 2′,3′-didehydro-3′-deoxythymidine-5′-triphosphate is efficiently incorporated into growing DNA chains
100 мМ ammonium salt water solution.
Purity  96% (HPLC).

 2’,3’-Didehydro-3’-deoxythymidine-5’-triphosphate (d4T-TP) is analog of thymidine and  inhibits the activity of HIV reverse transcriptase by competing with substrate deoxythymidine triphosphate and when incorporated causes termination of DNA chain elongation. Also d4T-TP inhibits cellular DNA polymerase and reduces synthesis of mitochondrial DNA.